Preventing Anti virus conflicts

I have HitmanPro, Anti-malwareBytes, and ESET installed on the computer. Is there a way to disable the real time functions of one or more of these to prevent conflicts and improve performance? Hitman does not seem to run all the time, rather periodically, on its own sked. AMB claims to be watching all the time, though I do not get alerts, and find pups and some actually malware during formal scans. ESET is all on-all the time. But it too seldom issues warnings. The computer is associated with a criminal law practice, and hence is FULL of sensitive info. Who what when where how why. Can I dispense with some or most of these? It seems to get "the slows" and occasionally freeze. No data losses noted, though.